Pyrazinamide

Pyrazinamide Drug Info

Pyrazinamide Drug Uses: Pyrazinamide is used in the treatment of tuberculosis.

How to Use Pyrazinamide: Take Pyrazinamide by mouth on an empty stomach (one hour before or two hours after meals) with a full glass of water as directed. Take all this medication as prescribed. Do not skip doses or stop taking this without your doctor's approval. Stopping therapy too soon may result in ineffective treatment. For best results, take this medication at evenly spaced intervals throughout the day and night to keep your blood level constant. Antacids may reduce the absorption of rifampin. Take this drug at least one hour before taking any antacids.

Pyrazinamide Precautions: Pyrazinamide has caused severe, even fatal, liver problems (e.g., hepatitis). Liver problems increase with age and with daily use of alcohol. Hepatitis can develop with use of this drug at any time during treatment. Stop using this medication and notify your doctor immediately if you develop unusual fatigue, weakness, loss of appetite, nausea, vomiting, dark urine, yellowing of the eyes or skin, or stomach or abdominal pain. Your doctor may decide to slowly restart isoniazid after these symptoms disappear and lab tests return to normal. People with active (acute) liver problems should not use this medication for preventative treatment until after the liver problems have stopped. Your doctor will monitor your liver function tests at least every month to discuss your progress. Tell your doctor if you have: liver disease, kidney disease, gout, diabetes, blood disorders, allergies (especially drug allergies). Alcohol can reduce the effectiveness of this medication and increase side effects. Limit alcohol consumption while using this medication. Use caution operating machinery or participating in activities requiring alertness if this medication makes you feel drowsy or dizzy. This medication should be used only if clearly needed during pregnancy or while breast-feeding. Discuss the risks and benefits with your doctor.

Pyrazinamide Drug Interactions: Pyrazinamide is not recommended for use with: delavirdine. Ask your doctor or pharmacist for more details. Inform your doctor about all the medicines you may use (both prescription and nonprescription), especially of: other MAO inhibitors (e.g., furazolidone, linezolid, moclobemide, phenelzine procarbazine, selegiline, isocarboxazid, tranylcypromine), adrenaline-like drugs (e.g., sympathomimetics such as ephedra, pseudoephedrine, phenylpropanolamine), serotonin-type drugs (including SSRI antidepressants and triptans such as sumatriptan), warfarin, oral medicines for diabetes, azole antifungals (e.g., itraconazole, ketoconazole), theophylline, halothane, verapamil, certain protease inhibitors (e.g., nelfinavir), corticosteroids (e.g., prednisone), disopyramide, beta-blockers (e.g., metoprolol), isoniazid, digitoxin, quinidine, mexiletine, phenytoin, cyclosporine, zidovudine, live vaccines. In very rare cases, a drug contained in this combination medication (isoniazid - INH) may cause flushing of the skin or symptoms of high blood pressure such as unusually fast or slow heartbeat, vomiting, sweating, headache, chest pain, sudden vision changes, one-sided weakness or slurred speech. Tell your doctor immediately should these symptoms occur. If these reactions do occur, it is important that you follow special dietary restrictions in order to limit the amount of tyramine and histamine in your diet while you are taking this medicine. Foods and beverages high in tyramine should be avoided (see list below). Excessive amounts of coffee, chocolate, sour cream, or avocados may also produce symptoms of high blood pressure in very rare cases. High tyramine content foods include: aged cheeses (cheddar, camembert, emmenthaler, brie, stilton blue, gruyere, gouda, brick, bleu, roquefort, boursault, parmesan, romano, provolone, liederdranz, colby, edam), aged/dried/fermented/salted/smoked/pickled/processed meats and fish (includes bacon, summer sausage, liverwurst, hot dogs, corned beef, pepperoni, salami, bologna, ham, mortadella, pickled or dried herring), banana peel, beef and chicken liver (stored, not fresh), bouillon cubes, commercial gravies, concentrated yeast extracts (marmite), fava beans, Italian green beans, broad beans, fermented bean curd, homemade yeast-leavened bread, kim chee (Korean fermented cabbage), miso, orange pulp, overripe or spoiled fruits, packaged soups, red wine, sauerkraut, sherry, snow pea pods, sourdough bread, soy sauce, soya bean, soya bean paste, tap beer and ale, vermouth. Consult your healthcare professional (e.g., doctor, pharmacist, or dietician) for more information, including specific recommendations for your diet if necessary. Rifampin can decrease the effectiveness of oral contraceptives. Discuss the use of other birth control methods with your doctor. Also report drugs which cause drowsiness such as: sedatives, tranquilizers, psychiatric medicines, anti-seizure or anti-anxiety drugs, narcotic pain relievers, certain antihistamines (e.g., diphenhydramine). Do not start or stop any medicine without doctor or pharmacist approval.

Pyrazinamide Possible Side Effects: Stomach upset, heartburn, gas, diarrhea, sweating, coughing, dizziness, trouble sleeping, acne, drowsiness or flushing may occur. If any of these effects persist or worsen, notify your doctor. Notify your doctor if you develop: weakness, unusual bruising or bleeding, headache, muscle aches, vomiting, yellowing of the eyes or skin, dark urine, pale stools, numbness or tingling of the hands or feet, joint pain, changes in vision, confusion, memory trouble, fever, sore throat, chills. This medication may cause urine, saliva, tears and sweat to turn red-orange in color. Do not be alarmed. This will disappear when the medication is stopped. Soft contact lenses may be permanently discolored by this medication. In the unlikely event you have an allergic reaction to this drug, seek immediate medical attention. Symptoms of an allergic reaction include: rash, itching, swelling, dizziness.

Pyrazinamide Overdose: Seek emergency medical attention immediately if an overdose is suspected. Symptoms of Pyrazinamide overdose include: rash, itching, swelling, dizziness.

Pyrazinamide Storage: Store Pyrazinamide at room temperature away from moisture and sunlight. Avoid excessive heat. Avoid freezing. Keep out of the reach of children. Dispense of this medicine in a tight, light-resistant container. Do not store Pyrazinamide in the bathroom.

Pyrazinamide Missed Dose: Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

Disclaimer: The information found on this website is for informational purposes only. It does not cover all possible uses, procedures, safety measures, side effects, or drug interactions of the products. We are not responsible for the accuracy and reliability of this drug information, or any consequences arising from the use of this information. This is only general information and should not be relied on for any purpose.

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